This function is used to generate a list object to be passed to getABSignal
Examples
library(GenomicRanges)
# Generate random genomic intervals of 1-1000 bp on chr1-22
# Modified from https://www.biostars.org/p/225520/
random_genomic_int <- data.frame(chr = rep("chr14", 100))
random_genomic_int$start <- apply(random_genomic_int, 1, function(x) {
round(runif(1, 0, getSeqLengths(getGenome("hg19"), chr = x)[[1]]), 0)
})
random_genomic_int$end <- random_genomic_int$start + runif(1, 1, 1000)
random_genomic_int$strand <- "*"
# Generate random counts
counts <- rnbinom(1000, 1.2, 0.4)
# Build random counts for 10 samples
count.mat <- matrix(sample(counts, nrow(random_genomic_int) * 10, replace = FALSE), ncol = 10)
colnames(count.mat) <- paste0("sample_", seq(1:10))
# Bin counts
bin.counts <- getBinMatrix(
count.mat,
makeGRangesFromDataFrame(random_genomic_int),
chr = "chr14",
genome = "hg19"
)
#> 1074 bins created...
# Calculate correlations
getCorMatrix(bin.counts)
#> Calculating correlations...
#> Done...
#> $gr.cor
#> GRanges object with 96 ranges and 0 metadata columns:
#> seqnames ranges strand
#> <Rle> <IRanges> <Rle>
#> [1] chr14 1000000-1099999 *
#> [2] chr14 6700000-6799999 *
#> [3] chr14 7100000-7199999 *
#> [4] chr14 7800000-7899999 *
#> [5] chr14 8600000-8699999 *
#> ... ... ... ...
#> [92] chr14 101100000-101199999 *
#> [93] chr14 102600000-102699999 *
#> [94] chr14 102800000-102899999 *
#> [95] chr14 103800000-103899999 *
#> [96] chr14 106800000-106899999 *
#> -------
#> seqinfo: 1 sequence from an unspecified genome; no seqlengths
#>
#> $binmat.cor
#> [,1] [,2] [,3] [,4] [,5]
#> [1,] 1.00000000 0.333150585 -0.577962193 -0.35931015 0.539009134
#> [2,] 0.33315058 1.000000000 0.025061861 -0.15498568 -0.199966950
#> [3,] -0.57796219 0.025061861 1.000000000 0.34569643 -0.364931513
#> [4,] -0.35931015 -0.154985679 0.345696427 1.00000000 -0.390061101
#> [5,] 0.53900913 -0.199966950 -0.364931513 -0.39006110 1.000000000
#> [6,] -0.79730996 -0.103719956 0.308463926 0.35325546 -0.391556696
#> [7,] 0.25338676 0.905198679 0.048386837 -0.32945552 -0.067004823
#> [8,] 0.38231987 0.026780378 0.205749695 0.36940118 0.115542290
#> [9,] -0.33772465 -0.186933635 0.058284245 -0.45285681 -0.156099418
#> [10,] -0.37534931 -0.415699584 0.057235818 0.16517828 -0.199278919
#> [11,] 0.10835083 -0.559104602 -0.289938751 0.32883988 0.273655481
#> [12,] 0.28513297 0.346193858 0.193046836 0.02210788 -0.315063019
#> [13,] -0.31469702 -0.095522251 0.083933876 0.41258423 -0.365292500
#> [14,] 0.40138494 -0.243670520 -0.286851688 -0.04149536 0.303891828
#> [15,] 0.66073764 -0.007162802 -0.356812292 -0.35495434 0.915515234
#> [16,] 0.35236129 -0.335124916 -0.418810939 0.07649728 0.726783324
#> [17,] 0.09746884 0.300080671 -0.260819364 0.36059023 -0.164114314
#> [18,] 0.07317073 0.333150585 -0.467874157 -0.39713227 0.000000000
#> [19,] -0.13413725 0.366440817 -0.010090720 -0.14560530 -0.175665150
#> [20,] -0.13085141 0.051066347 0.097029141 0.15363351 0.312123699
#> [21,] 0.60414045 0.145438596 -0.465445780 -0.54595438 0.439922158
#> [22,] 0.09626427 -0.578551791 -0.013034980 -0.03881220 0.482206176
#> [23,] -0.25747938 -0.338669799 0.109759684 0.29723810 0.435541057
#> [24,] 0.22447851 0.057654874 0.222126444 0.36684426 -0.118720830
#> [25,] 0.11287680 0.151733078 -0.010917467 0.16753718 0.601849234
#> [26,] 0.60335188 0.695931012 -0.258713004 -0.17776817 0.088891328
#> [27,] -0.08633789 0.047172170 0.284477726 -0.36684426 0.245921719
#> [28,] -0.42985413 -0.169619735 0.184318401 0.12664978 -0.010555008
#> [29,] -0.20546018 -0.145517881 0.633700784 -0.14868398 -0.235435478
#> [30,] -0.15491428 0.073892100 0.384572401 -0.38779444 0.282575312
#> [31,] 0.50442188 0.270888347 0.008756782 -0.17449312 0.247720179
#> [32,] -0.48634993 -0.425508209 -0.148498396 0.47469368 -0.407441634
#> [33,] -0.32337439 0.222142883 0.656813581 0.26656501 -0.016716659
#> [34,] 0.20586455 0.919459629 -0.059733782 0.05016559 -0.245527367
#> [35,] -0.29869671 -0.258048139 -0.150376188 0.46675407 -0.332871465
#> [36,] 0.00000000 0.627103203 0.266429945 0.00000000 0.217414138
#> [37,] -0.63537437 -0.168752287 0.645262154 0.17652924 -0.370536314
#> [38,] 0.12950244 -0.048044097 -0.250046131 -0.19412632 -0.007066476
#> [39,] -0.09455530 0.499398300 -0.132303571 -0.03225806 -0.120733198
#> [40,] -0.55877519 -0.205316228 0.391588129 0.40588524 -0.043328359
#> [41,] 0.02439024 0.777351364 0.412830138 0.05673318 -0.179669711
#> [42,] 0.34292247 -0.451055477 -0.197776759 0.33678910 0.299392475
#> [43,] -0.31273385 -0.348063313 -0.243101741 0.42568585 -0.307165447
#> [44,] -0.02752201 -0.275680469 -0.254658385 -0.17498214 0.162191784
#> [45,] 0.14304410 0.008683841 0.238888725 0.47469368 0.154546827
#> [46,] 0.04298541 0.104381376 -0.451095035 -0.65991202 -0.068607554
#> [47,] 0.34279520 0.266913682 0.010090720 -0.13173813 0.578231119
#> [48,] 0.21522676 -0.083994848 -0.228984532 0.03337536 -0.211394519
#> [49,] -0.22168564 -0.276635997 0.005558902 0.69135858 -0.145158930
#> [50,] 0.12895624 0.300096455 -0.378337771 0.13998134 -0.042220033
#> [51,] -0.32880508 0.099804574 0.519434214 0.68323965 -0.193770312
#> [52,] -0.03787770 -0.287432282 0.042741288 0.17621164 0.046504083
#> [53,] 0.31402432 -0.652562120 -0.288928105 -0.23598816 0.486375013
#> [54,] -0.13643902 -0.136075618 0.171553330 0.35968080 0.210586587
#> [55,] 0.66792615 -0.047703632 -0.381278198 -0.01827808 0.356959319
#> [56,] 0.25744482 -0.343833954 0.069720324 0.24751732 -0.050572174
#> [57,] -0.18157378 0.223699614 0.658052974 0.22028534 -0.110151644
#> [58,] -0.07165744 0.054376744 -0.444721319 -0.27779921 -0.263930754
#> [59,] 0.36804845 0.029399052 0.196724249 0.16521285 0.570781793
#> [60,] -0.34985827 0.048270454 0.586189827 -0.36990522 -0.234292392
#> [61,] -0.08058811 -0.334307024 0.078811041 0.34574631 -0.342997170
#> [62,] -0.16101751 0.635372437 0.641980296 0.35789039 -0.246011883
#> [63,] -0.25911712 -0.123595506 0.359220005 0.50513851 -0.290861019
#> [64,] -0.14256649 -0.021637116 0.128697890 0.25424067 -0.472594528
#> [65,] 0.12994442 0.690251917 -0.048876533 -0.38621930 -0.053179454
#> [66,] -0.54270038 -0.277981458 0.658313226 0.29454924 -0.116601906
#> [67,] -0.17460757 0.000000000 0.472866244 0.21661214 0.471621109
#> [68,] -0.12612169 0.331782748 -0.123340547 0.14342371 -0.289044049
#> [69,] 0.07935202 -0.106667861 -0.376072252 -0.53966976 0.022268319
#> [70,] -0.42150666 -0.046059462 0.026635230 0.48891771 -0.364321307
#> [71,] 0.23361262 0.181214750 -0.287040947 -0.31798791 0.101979116
#> [72,] -0.29962582 0.003637903 0.100077153 0.31037407 0.064743978
#> [73,] -0.24323744 -0.137115851 0.227417758 0.37180157 -0.392489182
#> [74,] 0.00000000 -0.313684383 0.331424894 -0.19399250 0.204786547
#> [75,] 0.16153751 -0.483321758 -0.536421956 0.16819107 0.181327128
#> [76,] 0.59865454 0.666284382 -0.247691842 -0.17019526 -0.208248282
#> [77,] -0.32666086 -0.113318540 -0.063189410 0.42695373 -0.068752387
#> [78,] -0.44823554 -0.507118411 -0.003065394 -0.25486339 -0.153422003
#> [79,] -0.14480004 -0.219760994 -0.070025447 -0.01603875 0.355554481
#> [80,] 0.41444213 0.779951346 -0.149650396 -0.29563202 -0.010176569
#> [81,] 0.27330408 -0.237022732 -0.308396977 0.09081740 0.287611871
#> [82,] 0.05950226 -0.120407668 0.000000000 0.01537843 -0.219160465
#> [83,] -0.12315869 -0.471028860 -0.116736946 0.53093283 -0.338704170
#> [84,] 0.26445343 0.416647063 -0.474613802 -0.61904027 -0.037106383
#> [85,] 0.23017684 0.435326610 -0.051946419 0.23887311 -0.426070848
#> [86,] -0.06848673 0.197488553 0.100464759 0.52039392 0.025225230
#> [87,] -0.14904416 -0.575199981 -0.254675280 0.22121852 -0.146390346
#> [88,] 0.55005683 0.190814526 -0.514282220 -0.20105885 -0.077180393
#> [89,] 0.29944952 0.381755087 0.229771693 0.43649695 0.029411765
#> [90,] -0.15373340 -0.009332761 -0.117961729 0.44341553 -0.392589820
#> [91,] 0.05521576 -0.167600381 0.186916795 -0.59936428 0.474535376
#> [92,] -0.58418691 -0.242651784 0.541236167 -0.29561036 -0.241593736
#> [93,] -0.59865454 -0.469427633 0.371537763 -0.28623748 -0.085749293
#> [94,] -0.45188205 -0.262895775 -0.263450805 0.28613413 -0.240411184
#> [95,] -0.04546394 -0.289799936 -0.123123883 -0.50760899 0.200944926
#> [96,] 0.54876666 0.620855901 -0.540418564 -0.33265436 -0.220498181
#> [,6] [,7] [,8] [,9] [,10]
#> [1,] -0.79730996 0.253386755 0.382319870 -0.337724646 -0.37534931
#> [2,] -0.10371996 0.905198679 0.026780378 -0.186933635 -0.41569958
#> [3,] 0.30846393 0.048386837 0.205749695 0.058284245 0.05723582
#> [4,] 0.35325546 -0.329455523 0.369401175 -0.452856813 0.16517828
#> [5,] -0.39155670 -0.067004823 0.115542290 -0.156099418 -0.19927892
#> [6,] 1.00000000 -0.127432909 -0.494423406 0.111328943 -0.04737475
#> [7,] -0.12743291 1.000000000 -0.136312576 -0.085729839 -0.38102737
#> [8,] -0.49442341 -0.136312576 1.000000000 -0.081444193 -0.18348161
#> [9,] 0.11132894 -0.085729839 -0.081444193 1.000000000 0.05784018
#> [10,] -0.04737475 -0.381027368 -0.183481606 0.057840179 1.00000000
#> [11,] -0.30359630 -0.403251691 0.212768047 -0.274845333 0.35409079
#> [12,] -0.59920160 0.402556157 0.435488971 -0.085156257 0.03953156
#> [13,] 0.42752638 -0.077732614 -0.462244883 -0.517309680 -0.01189920
#> [14,] -0.14058382 -0.443723395 0.016132705 -0.375972952 -0.22259611
#> [15,] -0.50692283 0.105604751 0.073979559 -0.445919734 -0.13740952
#> [16,] -0.13164100 -0.334149914 -0.050984342 -0.600792186 0.12701589
#> [17,] -0.01300501 0.393908568 -0.110810027 -0.474069182 -0.05212283
#> [18,] -0.04556057 0.565247377 -0.558775195 0.059598467 0.13187949
#> [19,] 0.20880513 0.564559419 -0.549915172 -0.094688927 -0.24176268
#> [20,] 0.31426489 0.188224139 0.193841243 0.118760674 -0.42762275
#> [21,] -0.40860362 0.136514311 0.005023857 0.111990592 -0.49389261
#> [22,] -0.35964011 -0.440033329 -0.060358140 -0.310497427 0.48847542
#> [23,] 0.50768758 -0.333792988 0.117286015 0.004660448 -0.24988316
#> [24,] -0.48383321 0.129713055 0.653775200 -0.194092251 -0.12209506
#> [25,] 0.18073027 0.146904777 0.143881762 -0.312594477 -0.19450125
#> [26,] -0.52126120 0.732889792 0.378304396 -0.068801261 -0.41406867
#> [27,] 0.09676664 0.339461825 -0.112432678 0.194092251 -0.45246993
#> [28,] 0.56207225 -0.212979209 0.145126430 0.574199282 -0.26818231
#> [29,] -0.09594905 -0.207976570 0.346835118 0.479736256 0.00000000
#> [30,] 0.18602825 0.307728034 -0.016010763 0.400169575 -0.52466973
#> [31,] -0.18120224 0.006201617 0.290074551 -0.233872940 -0.53257682
#> [32,] 0.24048359 -0.425243122 -0.089689306 0.191078350 0.67825429
#> [33,] 0.36561404 0.084327287 0.168280290 -0.102584427 0.04955276
#> [34,] 0.16480780 0.803774156 -0.134751773 -0.368894287 -0.42812375
#> [35,] 0.39701033 -0.271752291 -0.465440038 -0.475355465 0.19113263
#> [36,] 0.19296125 0.707578658 0.000000000 -0.192316583 -0.29461717
#> [37,] 0.23490110 -0.156557755 -0.108533733 0.168194095 0.72674180
#> [38,] 0.21502968 -0.292074443 0.010410080 0.302379833 -0.48477275
#> [39,] 0.37091823 0.661933573 -0.551821509 -0.255694663 -0.35395345
#> [40,] 0.38455154 -0.145713443 -0.290780142 -0.301822598 0.67276589
#> [41,] 0.00000000 0.721177688 0.323501428 0.099330778 -0.31448185
#> [42,] -0.17793707 -0.566357674 0.248093031 -0.614492111 -0.15847880
#> [43,] 0.42190895 -0.505391798 -0.092176973 -0.016981706 0.33241298
#> [44,] 0.02570533 -0.224338970 -0.537604041 -0.327288452 0.53801669
#> [45,] -0.32064479 -0.105167654 0.807203751 -0.135152979 0.22608476
#> [46,] -0.07025903 0.127100496 -0.352449901 0.738756393 0.07151528
#> [47,] -0.11136273 0.245357047 -0.097043854 -0.536570586 -0.16737416
#> [48,] 0.00000000 -0.407878413 -0.022244203 -0.195339698 -0.06394196
#> [49,] 0.55214010 -0.468485783 0.005940082 -0.509596519 -0.15367530
#> [50,] 0.46170220 0.075573268 -0.300619033 -0.399138525 -0.42909169
#> [51,] 0.29481716 -0.073573424 0.523335059 -0.096413692 0.13675911
#> [52,] 0.22995347 -0.302696936 -0.319704703 -0.555333416 -0.18905258
#> [53,] -0.56403095 -0.629306105 0.273788472 0.121985809 0.43202228
#> [54,] 0.21845642 -0.127725857 0.465342932 0.085729839 -0.18646020
#> [55,] -0.38531137 -0.238625875 0.255823633 -0.569635729 -0.24512553
#> [56,] -0.31258671 -0.403240967 0.509090959 -0.184528956 -0.32123523
#> [57,] 0.10973367 0.039263270 0.188028833 -0.227930899 0.19990999
#> [58,] 0.16731862 -0.057264527 -0.388813338 0.466926954 0.05960861
#> [59,] -0.43421581 -0.046440519 0.630641478 -0.299780021 0.05639845
#> [60,] 0.01980392 0.296531383 -0.115050388 0.526751439 -0.12787745
#> [61,] -0.25089541 -0.244725366 0.408119777 0.126904028 0.10055646
#> [62,] 0.10025934 0.597628475 0.297698774 -0.212755665 -0.08185421
#> [63,] 0.15557993 -0.218904256 0.607021891 0.205023987 -0.03079256
#> [64,] 0.16644489 -0.307613667 0.051571062 -0.127734386 0.29648669
#> [65,] -0.02022783 0.899982693 -0.443938383 -0.141121790 -0.27924529
#> [66,] 0.33263844 -0.075896646 -0.155414348 -0.121559949 0.01410775
#> [67,] 0.22831483 0.055814557 0.252645576 -0.113776025 -0.13072340
#> [68,] 0.39265536 0.047034982 0.070968224 0.315031548 -0.13988665
#> [69,] -0.11646506 -0.121391752 -0.483872125 0.164353009 0.45735081
#> [70,] 0.45667309 -0.115874345 -0.256154711 -0.107116586 0.17531626
#> [71,] -0.46062806 0.294555099 -0.056336993 0.054969885 0.52901456
#> [72,] 0.58208388 -0.178146210 0.135842122 0.177667629 -0.15453209
#> [73,] 0.42190895 -0.283241557 -0.259771469 -0.469827211 -0.13007465
#> [74,] -0.14393554 -0.098523413 0.244845156 0.215603926 -0.39966834
#> [75,] -0.08621410 -0.601197751 -0.127997220 -0.372167302 0.48951191
#> [76,] -0.30286661 0.502331015 0.096245934 -0.333201215 -0.58099289
#> [77,] 0.45764778 -0.231214552 -0.011253728 -0.060815843 0.32996337
#> [78,] 0.05074524 -0.349520482 -0.330834725 0.546533747 0.74008465
#> [79,] 0.27048406 -0.247962677 0.224481485 0.522312030 -0.18067901
#> [80,] -0.17418847 0.854492037 -0.259857118 -0.425335993 -0.41370703
#> [81,] -0.49229435 -0.156006430 0.423699512 0.000000000 0.38974188
#> [82,] -0.28713552 -0.158502691 0.597887687 0.630049287 -0.12374317
#> [83,] 0.20705254 -0.594465154 0.053460735 -0.292917684 -0.05122510
#> [84,] -0.10585598 0.368328567 -0.264208342 0.510807115 -0.25665146
#> [85,] -0.16537173 0.444295931 0.072587956 -0.429766172 -0.31666822
#> [86,] 0.19189809 0.125880555 0.520252677 -0.005578329 -0.19939864
#> [87,] 0.03977314 -0.452608791 -0.220791708 -0.100587177 0.13283911
#> [88,] -0.25687425 -0.050237026 0.161074139 -0.057603613 -0.34317574
#> [89,] -0.33562002 0.354168351 0.317741298 -0.819521946 0.04981973
#> [90,] 0.20102000 -0.034399384 -0.274345166 -0.405705527 0.06394196
#> [91,] -0.10314212 0.088250564 -0.066577955 0.404765304 -0.45931521
#> [92,] 0.21537857 -0.034399384 -0.311418837 0.495862311 0.35807500
#> [93,] 0.20967688 -0.295019802 -0.144368901 0.845193327 0.35274569
#> [94,] 0.47481083 -0.216670986 -0.508544832 0.042940745 0.31325037
#> [95,] 0.21231470 -0.123529419 -0.460483134 0.251810405 -0.47274270
#> [96,] -0.34946147 0.534225048 0.024061483 0.048761153 -0.35274569
#> [,11] [,12] [,13] [,14] [,15]
#> [1,] 0.10835083 0.285132974 -0.314697016 0.40138494 0.660737640
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#> [3,] -0.28993875 0.193046836 0.083933876 -0.28685169 -0.356812292
#> [4,] 0.32883988 0.022107884 0.412584231 -0.04149536 -0.354954337
#> [5,] 0.27365548 -0.315063019 -0.365292500 0.30389183 0.915515234
#> [6,] -0.30359630 -0.599201596 0.427526384 -0.14058382 -0.506922831
#> [7,] -0.40325169 0.402556157 -0.077732614 -0.44372340 0.105604751
#> [8,] 0.21276805 0.435488971 -0.462244883 0.01613270 0.073979559
#> [9,] -0.27484533 -0.085156257 -0.517309680 -0.37597295 -0.445919734
#> [10,] 0.35409079 0.039531559 -0.011899198 -0.22259611 -0.137409515
#> [11,] 1.00000000 0.217143448 0.112566631 -0.11038275 0.287534714
#> [12,] 0.21714345 1.000000000 -0.122631678 -0.41058249 -0.101151831
#> [13,] 0.11256663 -0.122631678 1.000000000 0.28248547 -0.226970108
#> [14,] -0.11038275 -0.410582491 0.282485472 1.00000000 0.313910926
#> [15,] 0.28753471 -0.101151831 -0.226970108 0.31391093 1.000000000
#> [16,] 0.46810645 -0.430234112 0.071639753 0.46389865 0.786371760
#> [17,] 0.44006328 0.303854606 0.525905144 -0.27115635 -0.010777365
#> [18,] 0.17026558 0.190088650 0.028608820 -0.53517992 0.117988864
#> [19,] -0.15322864 0.034847225 0.597883825 -0.14716451 -0.112475097
#> [20,] 0.16845610 -0.152971210 -0.267500124 -0.48194990 0.141068431
#> [21,] -0.24590700 -0.178596376 -0.083081174 0.55424952 0.334582233
#> [22,] 0.48629100 -0.105034799 0.185179443 0.39076938 0.525289967
#> [23,] 0.10530427 -0.657751728 -0.127516779 0.03138727 0.199290827
#> [24,] 0.50189739 0.780547713 0.044559253 -0.26522419 -0.046778288
#> [25,] 0.03888734 -0.433576554 -0.261017446 -0.07076529 0.549166693
#> [26,] 0.05360641 0.628933174 -0.346777209 -0.40130640 0.195555642
#> [27,] -0.01972522 0.161492630 -0.125576075 -0.37415555 0.213843603
#> [28,] -0.22914925 -0.469017647 -0.383193819 -0.25938058 -0.336868962
#> [29,] -0.41724935 0.213504205 -0.353462116 0.03756904 -0.324681357
#> [30,] -0.25561294 -0.034495579 -0.306308610 -0.33991874 0.132751661
#> [31,] -0.55651522 -0.181443685 -0.154743807 0.71304846 0.285311338
#> [32,] 0.50473425 -0.044593337 0.140939597 -0.36095366 -0.492691211
#> [33,] -0.48173137 -0.245393919 -0.227583448 -0.10736767 -0.006586685
#> [34,] -0.45913105 0.148983069 0.158681079 -0.18552611 -0.039835147
#> [35,] 0.29746460 -0.219362918 0.932496003 0.29619561 -0.231193328
#> [36,] -0.26222563 0.000000000 -0.207713203 -0.48570658 0.285551160
#> [37,] -0.13104821 0.067056650 -0.099369299 -0.37395501 -0.312487863
#> [38,] -0.52781448 -0.510254525 -0.104643176 0.59594482 -0.197687243
#> [39,] -0.08881077 -0.022107884 0.519057581 -0.29565445 -0.010977969
#> [40,] 0.16050923 -0.263585430 0.255269562 -0.21779152 0.039835147
#> [41,] -0.51079675 0.285132974 -0.314697016 -0.46828243 -0.165184410
#> [42,] 0.43041904 -0.133630621 0.411173441 0.77335488 0.357585614
#> [43,] 0.27785676 -0.243733339 0.057061636 -0.06671509 -0.322744235
#> [44,] 0.22007399 -0.193046836 0.174324204 0.17362076 0.356812292
#> [45,] 0.32317517 0.289856694 -0.530201342 -0.28248547 0.143932264
#> [46,] -0.37100354 -0.180069275 -0.373109771 -0.09432021 -0.234976498
#> [47,] -0.24403080 -0.354280120 0.101395502 0.45375723 0.674850584
#> [48,] -0.31610493 -0.227646966 0.223600981 0.79271988 -0.142788861
#> [49,] 0.17820420 -0.403138599 0.537392728 0.38509119 -0.128689667
#> [50,] -0.31644420 -0.494143593 0.332773579 0.40675592 0.024953256
#> [51,] -0.02504020 0.000000000 -0.262259502 -0.36073825 -0.229047678
#> [52,] 0.04807637 -0.295204962 0.799723600 0.70126322 0.146588019
#> [53,] 0.48748930 0.009413042 -0.447672909 0.29151861 0.425349760
#> [54,] 0.27955485 -0.060763194 -0.425243122 -0.41164701 0.064117170
#> [55,] 0.14461907 0.015310507 0.009217079 0.68968881 0.520780805
#> [56,] 0.33983299 0.361157559 0.217420482 0.41661015 -0.044834418
#> [57,] -0.50024024 -0.066593869 -0.102731084 0.12011072 -0.002066755
#> [58,] -0.38654337 -0.383949416 0.042025711 0.19654181 -0.415975153
#> [59,] 0.11063994 0.000000000 -0.431706702 0.15939193 0.562247485
#> [60,] -0.28931084 0.351161727 -0.037306393 -0.39255964 -0.297461714
#> [61,] 0.61712953 0.617606388 0.119733896 -0.28734789 -0.369056568
#> [62,] -0.31109941 0.327671365 -0.054561680 -0.47598799 -0.131552484
#> [63,] 0.19263268 0.274070138 -0.356037481 -0.44672929 -0.383209901
#> [64,] -0.21714345 0.041666667 -0.016722502 0.16618815 -0.324145640
#> [65,] -0.20616536 0.337579789 0.177823124 -0.43066352 0.146676086
#> [66,] 0.09471328 -0.026435053 0.580867119 -0.05116777 -0.144393516
#> [67,] -0.06648633 -0.340206909 -0.245769576 -0.14367394 0.354762124
#> [68,] -0.53893692 -0.393178550 -0.286009408 -0.04035806 -0.439285792
#> [69,] -0.12805543 -0.114853269 -0.215406487 0.11193248 0.129418645
#> [70,] -0.02353993 -0.354787438 0.597248637 0.08786415 -0.437173768
#> [71,] 0.28662962 0.434942942 -0.468876324 -0.51972107 0.266203968
#> [72,] -0.29054983 -0.625826679 -0.306464037 -0.06903228 -0.148423979
#> [73,] -0.16318572 -0.176029634 0.790711241 0.55278221 -0.255505852
#> [74,] 0.18869831 0.286135135 -0.093571285 -0.06464622 0.115772371
#> [75,] 0.49500555 -0.260785462 0.113686375 0.40508763 0.272389295
#> [76,] -0.34192970 0.417968488 0.163846384 0.28734789 0.014480087
#> [77,] 0.16584605 -0.327326835 -0.197054046 -0.31358756 -0.094814166
#> [78,] 0.22929365 0.010586012 -0.264474758 -0.39862983 -0.218150044
#> [79,] -0.09189391 -0.564259306 -0.558061775 -0.11347347 0.000000000
#> [80,] -0.22093332 0.395676293 0.213894872 -0.13640768 0.276673691
#> [81,] 0.74333978 0.380362887 -0.503761022 -0.40158088 0.302198943
#> [82,] 0.11328510 0.386449080 -0.488557087 -0.27200439 -0.431767171
#> [83,] 0.38454591 -0.028795614 0.618290559 0.42562710 -0.324107310
#> [84,] -0.54184820 -0.152125369 -0.268834554 0.05526416 -0.148643050
#> [85,] 0.17753885 0.662368320 0.502594157 -0.12626567 -0.185010724
#> [86,] 0.17820024 0.020016019 -0.329362426 -0.48370136 -0.089453027
#> [87,] 0.59184650 0.008297113 0.654337818 0.22775883 -0.181281914
#> [88,] -0.15459280 0.130139310 -0.175124505 0.39333815 0.007602639
#> [89,] 0.25845240 0.490098029 0.295043942 -0.01642659 0.330280812
#> [90,] 0.19902903 -0.011981419 0.858339249 0.21926295 -0.303426329
#> [91,] -0.17520687 -0.107582871 -0.194297910 0.07572282 0.293819517
#> [92,] -0.15219867 0.137786321 -0.151471632 -0.45539227 -0.258804810
#> [93,] -0.12030860 -0.165243356 -0.362802708 -0.36260567 -0.347522080
#> [94,] 0.20552296 -0.447562544 0.547708309 -0.02065701 -0.349759850
#> [95,] -0.16734514 -0.327754635 0.255971788 0.35539033 0.079176162
#> [96,] -0.16463282 0.456849277 -0.163846384 -0.11630748 -0.086880520
#> [,16] [,17] [,18] [,19] [,20] [,21]
#> [1,] 0.352361294 0.09746884 0.07317073 -0.13413725 -0.13085141 0.604140446
#> [2,] -0.335124916 0.30008067 0.33315058 0.36644082 0.05106635 0.145438596
#> [3,] -0.418810939 -0.26081936 -0.46787416 -0.01009072 0.09702914 -0.465445780
#> [4,] 0.076497276 0.36059023 -0.39713227 -0.14560530 0.15363351 -0.545954381
#> [5,] 0.726783324 -0.16411431 0.00000000 -0.17566515 0.31212370 0.439922158
#> [6,] -0.131641004 -0.01300501 -0.04556057 0.20880513 0.31426489 -0.408603618
#> [7,] -0.334149914 0.39390857 0.56524738 0.56455942 0.18822414 0.136514311
#> [8,] -0.050984342 -0.11081003 -0.55877519 -0.54991517 0.19384124 0.005023857
#> [9,] -0.600792186 -0.47406918 0.05959847 -0.09468893 0.11876067 0.111990592
#> [10,] 0.127015887 -0.05212283 0.13187949 -0.24176268 -0.42762275 -0.493892606
#> [11,] 0.468106449 0.44006328 0.17026558 -0.15322864 0.16845610 -0.245907003
#> [12,] -0.430234112 0.30385461 0.19008865 0.03484722 -0.15297121 -0.178596376
#> [13,] 0.071639753 0.52590514 0.02860882 0.59788382 -0.26750012 -0.083081174
#> [14,] 0.463898652 -0.27115635 -0.53517992 -0.14716451 -0.48194990 0.554249520
#> [15,] 0.786371760 -0.01077737 0.11798886 -0.11247510 0.14106843 0.334582233
#> [16,] 1.000000000 0.04559608 -0.02349075 -0.26699347 0.08281690 0.044141124
#> [17,] 0.045596075 1.00000000 0.54304067 0.62793526 0.15153757 -0.054707813
#> [18,] -0.023490753 0.54304067 1.00000000 0.49183660 0.13085141 -0.062497288
#> [19,] -0.266993470 0.62793526 0.49183660 1.00000000 -0.02056097 0.297883556
#> [20,] 0.082816903 0.15153757 0.13085141 -0.02056097 1.00000000 -0.213948344
#> [21,] 0.044141124 -0.05470781 -0.06249729 0.29788356 -0.21394834 1.000000000
#> [22,] 0.582244730 -0.06814569 -0.17327569 -0.04941231 -0.38069664 0.121688802
#> [23,] 0.424327769 -0.19925599 -0.31469702 -0.28320813 0.74987740 -0.161275221
#> [24,] -0.242809162 0.47120612 -0.08633789 0.08230321 0.13498820 -0.067844246
#> [25,] 0.580843386 0.03498178 -0.01612526 -0.15962923 0.66983858 -0.090902193
#> [26,] -0.220818299 0.47878119 0.45251391 0.19909263 0.30519599 0.216443093
#> [27,] -0.123067657 -0.09660711 0.22447851 0.17093744 0.57965521 -0.109140744
#> [28,] -0.215280773 -0.37791439 -0.25791248 -0.29944476 0.67207152 -0.154203477
#> [29,] -0.514495755 -0.76632691 -0.61638053 -0.40176157 -0.23095283 -0.046797231
#> [30,] -0.225933203 -0.30574571 0.02213061 0.10548210 0.64791939 0.026463374
#> [31,] 0.156956985 -0.50062278 -0.58202525 -0.29875272 -0.22006273 0.470611656
#> [32,] -0.071639753 0.32338267 0.20026174 -0.07342433 -0.03946723 -0.454502896
#> [33,] 0.036062473 -0.43334969 -0.42549262 -0.31824692 0.21653312 -0.404129536
#> [34,] -0.164282879 0.46002951 0.38231987 0.42052337 0.14876188 0.005023857
#> [35,] 0.203589654 0.55616614 0.09190668 0.45490724 -0.30640832 -0.113825312
#> [36,] 0.056851227 0.20219104 0.29514067 0.21642183 0.63336098 -0.201670704
#> [37,] -0.188682214 -0.37481912 -0.13236966 -0.27178062 -0.22724832 -0.687409934
#> [38,] -0.102552899 -0.50766300 -0.44606394 -0.22685371 -0.11248635 0.498982403
#> [39,] -0.076497276 0.71902124 0.66188712 0.83896388 0.31016578 0.029074494
#> [40,] 0.334230685 0.07723123 0.02940922 0.01078265 -0.01352381 -0.607886718
#> [41,] -0.493305811 0.12531708 0.02439024 0.22356209 0.31778199 0.020832429
#> [42,] 0.601835875 0.03915413 -0.49533245 -0.23748947 -0.19857591 0.175740137
#> [43,] 0.194106990 -0.02777231 0.03474821 -0.49686568 0.09054730 -0.599525316
#> [44,] 0.577853068 -0.11626887 0.30274210 -0.19172368 -0.35014864 -0.333804549
#> [45,] 0.148790257 -0.03593141 -0.31469702 -0.59788382 0.31135260 -0.356760337
#> [46,] -0.385021382 -0.22331305 0.36537601 0.14184225 -0.22731831 0.466281943
#> [47,] 0.554083222 -0.01531549 -0.13413725 0.20218579 -0.07082112 0.389540035
#> [48,] 0.100683413 -0.35456935 -0.46120019 -0.30437150 -0.65509945 0.246859499
#> [49,] 0.384318113 0.13218267 -0.36947606 -0.18965153 0.16235203 -0.332411395
#> [50,] 0.298081070 0.13251544 0.04298541 0.06304100 0.08565617 0.080773250
#> [51,] -0.038001485 -0.08259292 -0.38141390 -0.45810405 0.43344220 -0.617852738
#> [52,] 0.364808043 0.08649584 -0.30302161 0.27775099 -0.31933058 0.161762327
#> [53,] 0.451338576 -0.47162590 -0.21740145 -0.68195021 -0.25548372 0.070149183
#> [54,] 0.146425243 -0.08234247 -0.13643902 -0.49309620 0.85746552 -0.469476044
#> [55,] 0.582748337 -0.16149669 -0.27502842 -0.46096878 -0.23487584 0.181216216
#> [56,] -0.039672077 -0.01763669 -0.51488965 -0.20765809 -0.13417058 0.140730395
#> [57,] 0.006172147 -0.44999967 -0.52335973 -0.28587033 -0.23084344 -0.268210220
#> [58,] -0.310566476 -0.04090844 0.14331487 0.26272613 -0.38443553 0.489637897
#> [59,] 0.429101490 -0.18799743 -0.44553234 -0.39062145 0.13361589 0.115817238
#> [60,] -0.684122385 -0.19973021 0.03180530 0.36926982 0.02437607 0.027165846
#> [61,] -0.346685209 0.34045076 -0.02686270 -0.02954697 0.03705838 -0.215675764
#> [62,] -0.313604848 0.23082914 -0.05367250 0.20334537 0.26600912 -0.308678034
#> [63,] -0.263821742 -0.14370060 -0.29613385 -0.58359093 0.50498943 -0.613371469
#> [64,] -0.027461752 -0.39880917 -0.28513297 -0.60111463 -0.39335454 -0.511435075
#> [65,] -0.208586979 0.50692285 0.75800914 0.71464592 0.14938711 0.055494689
#> [66,] -0.124137939 0.16265635 -0.23743142 0.48500560 0.06758926 -0.139060936
#> [67,] 0.302702757 -0.17942675 -0.31429363 -0.12803688 0.61558089 -0.149137497
#> [68,] -0.267234951 -0.17280354 -0.12612169 -0.18496595 0.13532625 0.050271325
#> [69,] 0.181237828 -0.41288799 0.32874410 -0.30340647 -0.48827052 -0.091014710
#> [70,] -0.107173930 0.46009121 -0.05058080 0.51307934 -0.15247922 0.077764603
#> [71,] 0.104998688 0.10965719 0.64892394 -0.19985503 -0.06763896 -0.305954358
#> [72,] 0.108504531 -0.30242181 -0.29962582 -0.38229665 0.55296792 -0.210877488
#> [73,] 0.060240100 0.01190242 -0.38223027 0.14014160 -0.38882077 -0.124653779
#> [74,] -0.153663098 -0.24426977 -0.21756417 -0.07312078 0.32793090 0.018582799
#> [75,] 0.697888070 -0.02898342 0.02307679 -0.48227217 -0.31481800 -0.208932003
#> [76,] -0.211411450 0.23353958 0.09977576 0.21949179 -0.27529083 0.366452134
#> [77,] 0.305624923 -0.03729741 0.09333167 -0.49617979 0.40772574 -0.685569168
#> [78,] -0.107272151 -0.33653767 0.28524080 -0.29382339 -0.17280832 -0.443179311
#> [79,] 0.059768546 -0.36608670 -0.22754292 -0.34129126 0.61830032 0.123678000
#> [80,] -0.047898944 0.48739686 0.58021899 0.54702655 0.01270539 0.134515171
#> [81,] 0.300828419 0.15602627 0.27330408 -0.50102354 0.26931144 -0.333481580
#> [82,] -0.573078711 -0.13587673 -0.19834088 -0.29088024 0.15201150 0.118586169
#> [83,] 0.090148693 0.20530499 -0.32021259 -0.08127923 -0.20010831 -0.130439914
#> [84,] -0.380838061 -0.07045431 0.31482551 0.30934757 -0.19495999 0.673330067
#> [85,] -0.283078675 0.72576217 0.30100048 0.47389611 -0.07870648 -0.039320170
#> [86,] -0.013192199 0.25804886 -0.03424336 -0.22599088 0.78209027 -0.333430272
#> [87,] 0.069723093 0.43516261 0.06387607 0.33568149 -0.22519577 0.098205195
#> [88,] 0.015136320 -0.18392679 -0.03928977 -0.38894241 -0.23487584 0.214774775
#> [89,] 0.253797351 0.54020962 0.00000000 0.17566515 -0.08262098 -0.184153462
#> [90,] -0.041457876 0.70562812 0.09224004 0.64256207 -0.33461914 0.120803584
#> [91,] -0.106358907 -0.37826480 -0.11043153 0.20244408 0.25390926 0.471614174
#> [92,] -0.367198330 -0.47041875 0.09224004 -0.09018415 -0.02827767 -0.483214338
#> [93,] -0.403603676 -0.56391264 -0.09977576 -0.14632786 0.06882271 -0.144876425
#> [94,] 0.029014469 0.48585189 0.26359786 0.49703659 -0.07503803 0.025731056
#> [95,] -0.017514908 -0.25435762 0.00000000 0.28337269 0.02787541 0.411620223
#> [96,] -0.317117174 0.30758871 0.49887878 0.14632786 -0.10705755 0.272708565
#> [,22] [,23] [,24] [,25] [,26]
#> [1,] 0.096264272 -0.257479377 0.224478511 0.112876801 0.603351880
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