This function is used to generate a list object to be passed to getABSignal
Examples
library(GenomicRanges)
# Generate random genomic intervals of 1-1000 bp on chr1-22
# Modified from https://www.biostars.org/p/225520/
random_genomic_int <- data.frame(chr = rep("chr14", 100))
random_genomic_int$start <- apply(random_genomic_int, 1, function(x) {
round(runif(1, 0, getSeqLengths(getGenome("hg19"), chr = x)[[1]]), 0)
})
random_genomic_int$end <- random_genomic_int$start + runif(1, 1, 1000)
random_genomic_int$strand <- "*"
# Generate random counts
counts <- rnbinom(1000, 1.2, 0.4)
# Build random counts for 10 samples
count.mat <- matrix(sample(counts, nrow(random_genomic_int) * 10, replace = FALSE), ncol = 10)
colnames(count.mat) <- paste0("sample_", seq(1:10))
# Bin counts
bin.counts <- getBinMatrix(
count.mat,
makeGRangesFromDataFrame(random_genomic_int),
chr = "chr14",
genome = "hg19"
)
# Calculate correlations
getCorMatrix(bin.counts)
#> $gr.cor
#> GRanges object with 94 ranges and 0 metadata columns:
#> seqnames ranges strand
#> <Rle> <IRanges> <Rle>
#> [1] chr14 1100000-1199999 *
#> [2] chr14 3900000-3999999 *
#> [3] chr14 4000000-4099999 *
#> [4] chr14 5700000-5799999 *
#> [5] chr14 6400000-6499999 *
#> ... ... ... ...
#> [90] chr14 104100000-104199999 *
#> [91] chr14 105400000-105499999 *
#> [92] chr14 106200000-106299999 *
#> [93] chr14 107100000-107199999 *
#> [94] chr14 107200000-107299999 *
#> -------
#> seqinfo: 1 sequence from an unspecified genome; no seqlengths
#>
#> $binmat.cor
#> [,1] [,2] [,3] [,4] [,5]
#> [1,] 1.000000000 0.15603522 0.073462542 0.306342723 -0.132141641
#> [2,] 0.156035217 1.00000000 0.223615943 0.197931389 -0.360186753
#> [3,] 0.073462542 0.22361594 1.000000000 0.197372434 -0.322166358
#> [4,] 0.306342723 0.19793139 0.197372434 1.000000000 -0.210940813
#> [5,] -0.132141641 -0.36018675 -0.322166358 -0.210940813 1.000000000
#> [6,] -0.585317413 -0.48962035 -0.331641364 -0.066569891 0.767607113
#> [7,] 0.227830594 -0.36729122 0.123435483 0.222587050 0.181249858
#> [8,] 0.021927768 -0.31582690 0.276213797 -0.195485774 -0.271699051
#> [9,] -0.308484083 -0.10469782 -0.225737313 0.007828163 0.617995734
#> [10,] 0.104168348 0.05343301 0.754203258 0.164221230 -0.150297454
#> [11,] -0.459578629 -0.28054465 0.055331862 -0.049889042 -0.063982839
#> [12,] -0.078145249 0.03978311 -0.235883262 0.294480238 -0.049734551
#> [13,] -0.007993672 -0.38338205 -0.409266393 -0.241124375 0.032273642
#> [14,] 0.362719863 0.45010322 -0.133350573 0.041132444 0.357093693
#> [15,] 0.347621076 0.05926346 -0.408062024 0.187105762 -0.166697454
#> [16,] 0.202644332 -0.25021935 -0.387153901 -0.419405958 0.555336404
#> [17,] 0.698310821 0.27403461 0.216191543 0.094417022 0.045137528
#> [18,] 0.302620771 0.36538992 -0.049618194 0.098227791 -0.329287518
#> [19,] 0.133384206 -0.19196168 -0.550331318 -0.568872282 0.368539841
#> [20,] -0.169880452 -0.06966827 0.122718523 -0.525573681 -0.243266073
#> [21,] 0.163770074 0.09321678 -0.099819420 -0.276668204 -0.091200710
#> [22,] -0.622013686 -0.54556707 -0.321324114 -0.045930661 0.004027775
#> [23,] 0.235987442 0.63073125 0.450271078 0.608969007 -0.488529556
#> [24,] 0.353369901 0.47499316 0.307329161 -0.163533343 -0.326249745
#> [25,] -0.372920862 -0.20764950 -0.176787970 0.170783462 -0.051918288
#> [26,] 0.449236202 -0.21679091 0.182542497 -0.284597264 0.199355684
#> [27,] -0.496220138 -0.14058733 0.327558576 -0.037613761 0.316039879
#> [28,] -0.005887346 0.71857869 0.711299338 0.113599002 -0.595058779
#> [29,] -0.620503829 -0.28238960 -0.137528362 -0.102349316 0.480176820
#> [30,] 0.160474923 0.13956481 0.608601743 0.333160849 -0.584068664
#> [31,] -0.102215986 0.23272249 0.627631107 0.457707592 -0.009487051
#> [32,] -0.313504428 -0.25935415 0.121323134 -0.464903087 -0.280583311
#> [33,] -0.116909529 -0.32001540 -0.374532026 -0.047177349 -0.260419544
#> [34,] 0.070604850 -0.27257802 -0.153010947 0.224184585 -0.019659307
#> [35,] -0.307206711 0.33885894 0.237771959 0.578834326 0.268836985
#> [36,] -0.440639391 -0.44907671 -0.233306627 -0.364455720 0.092019159
#> [37,] 0.372907619 0.09325682 -0.393438954 0.594425184 0.338823109
#> [38,] -0.603406770 -0.15824912 -0.016982727 0.187574324 0.205107237
#> [39,] 0.272835829 -0.23176668 -0.323138554 -0.522264741 0.492913630
#> [40,] -0.142324644 0.30391400 -0.099140830 -0.084422624 -0.137758165
#> [41,] -0.076140231 -0.23176668 0.553460714 0.361091053 -0.107769647
#> [42,] -0.040664184 -0.38039567 -0.374532026 -0.680347030 0.220790483
#> [43,] 0.045795673 -0.33417026 -0.287104102 -0.092679195 -0.426261330
#> [44,] 0.512873874 0.25001548 0.450880170 0.574339704 -0.379915924
#> [45,] -0.217579265 -0.27042394 0.157175271 0.084635011 0.020194352
#> [46,] -0.039862050 0.07102706 0.448731654 0.222849777 -0.039463971
#> [47,] 0.130858267 0.07217045 -0.212691629 -0.299069610 -0.229028474
#> [48,] -0.146280429 -0.21255029 -0.116048633 -0.207990576 0.816064964
#> [49,] -0.385983475 -0.41291271 -0.275658892 -0.163909955 0.355396140
#> [50,] 0.359197193 0.67113763 0.051354915 -0.149876454 -0.054174975
#> [51,] -0.545582365 -0.48092165 -0.473880814 -0.186135970 0.532900007
#> [52,] -0.396475794 0.43473791 -0.154219070 0.288030129 -0.232113072
#> [53,] -0.354061816 0.57454684 -0.058232839 -0.024708075 -0.084501804
#> [54,] 0.216538538 0.39026789 -0.311498461 0.590894670 -0.079004982
#> [55,] 0.118868136 0.18322537 -0.254537766 0.720297225 -0.184402030
#> [56,] -0.319554600 0.02460324 -0.346260575 0.211024087 0.161477147
#> [57,] -0.319897649 -0.36812533 -0.173316147 -0.341835345 0.144743174
#> [58,] 0.186440678 -0.10570128 -0.211204808 0.293923423 0.132141641
#> [59,] 0.675398225 -0.24201392 0.429428502 0.389913649 0.059059779
#> [60,] 0.263320038 -0.13033036 -0.142663175 -0.042876617 -0.171078081
#> [61,] -0.287289059 0.49666277 -0.005558902 -0.433545836 -0.397108821
#> [62,] -0.540743897 -0.02102897 -0.167410061 -0.187105762 0.310093113
#> [63,] 0.215485094 -0.25730383 -0.107017956 0.091008498 0.573749552
#> [64,] -0.264336362 -0.09744832 -0.138275399 -0.187010528 0.401004896
#> [65,] -0.194074170 -0.37462266 0.052573358 0.023700942 0.891631409
#> [66,] 0.038390615 0.01710131 0.093597784 -0.248484217 0.780335943
#> [67,] 0.350112400 -0.09242042 -0.484753324 0.513081792 0.238298518
#> [68,] 0.258602901 0.47009298 -0.080667952 -0.080388996 -0.209471221
#> [69,] 0.518605233 -0.03242323 -0.399277681 -0.290001611 0.148201153
#> [70,] -0.128769916 -0.06239294 -0.286406843 -0.130772300 -0.164177539
#> [71,] -0.087576985 -0.11847979 -0.015816002 0.192513131 -0.384741913
#> [72,] 0.353372078 0.08533663 0.077843175 0.916211682 -0.380598594
#> [73,] 0.316981696 -0.43873230 -0.177869764 -0.413375950 -0.137119458
#> [74,] -0.015007928 0.01559918 -0.239867128 0.298748828 -0.064771823
#> [75,] 0.362719863 -0.10771701 0.094749091 0.009492103 -0.328237637
#> [76,] -0.191415986 0.12451730 -0.182721062 0.187010528 0.258876578
#> [77,] -0.207243058 0.56509521 0.005103702 -0.085130835 -0.304262884
#> [78,] 0.322372541 0.13439729 -0.070534562 -0.004542593 0.226130776
#> [79,] 0.167405076 0.71715562 0.277882524 0.184431240 -0.192400489
#> [80,] 0.183692710 -0.22939509 0.109729588 0.614322514 -0.364590869
#> [81,] -0.185406974 -0.40377594 -0.179974617 0.464170773 -0.025812481
#> [82,] -0.373591023 -0.38449787 0.004635263 -0.415144469 -0.085759565
#> [83,] -0.530408928 0.03983155 -0.046243169 -0.136995802 -0.044136572
#> [84,] 0.037879399 -0.44714993 0.220617279 -0.048572477 -0.245222163
#> [85,] -0.484841462 0.45728090 0.216468137 0.117324209 0.063749950
#> [86,] 0.075993511 -0.30900543 -0.424390771 -0.431189284 0.641302681
#> [87,] -0.179394071 0.03887613 0.042029509 -0.197765573 -0.325354698
#> [88,] 0.097037085 0.46107404 0.525733582 0.355514125 -0.594420940
#> [89,] -0.272783639 -0.14851581 0.073895212 -0.499697805 0.037977118
#> [90,] 0.459334003 0.07897336 0.006548970 -0.153523974 0.114434663
#> [91,] 0.068761135 0.44203319 0.830541434 0.179801522 -0.286062883
#> [92,] 0.445730723 0.23072611 -0.020124231 -0.386330359 0.057745555
#> [93,] -0.315302109 -0.11344282 -0.045991709 -0.602761910 -0.457537295
#> [94,] 0.188071851 -0.18415981 -0.085371271 -0.320309368 -0.118887183
#> [,6] [,7] [,8] [,9] [,10]
#> [1,] -0.585317413 0.22783059 0.02192777 -0.308484083 0.104168348
#> [2,] -0.489620352 -0.36729122 -0.31582690 -0.104697824 0.053433010
#> [3,] -0.331641364 0.12343548 0.27621380 -0.225737313 0.754203258
#> [4,] -0.066569891 0.22258705 -0.19548577 0.007828163 0.164221230
#> [5,] 0.767607113 0.18124986 -0.27169905 0.617995734 -0.150297454
#> [6,] 1.000000000 0.03431991 -0.39885559 0.642122333 -0.072395780
#> [7,] 0.034319911 1.00000000 0.31580697 -0.384660909 -0.072739297
#> [8,] -0.398855592 0.31580697 1.00000000 -0.261745882 -0.073509046
#> [9,] 0.642122333 -0.38466091 -0.26174588 1.000000000 0.138780622
#> [10,] -0.072395780 -0.07273930 -0.07350905 0.138780622 1.000000000
#> [11,] 0.282688910 0.49029034 0.01651596 -0.156911479 0.185449547
#> [12,] 0.052972346 -0.12862394 0.10109950 0.517195405 0.074848119
#> [13,] 0.150669206 -0.07675069 -0.06722118 -0.013226300 -0.274673346
#> [14,] -0.092203887 -0.09950372 -0.25977147 0.018372092 -0.383605019
#> [15,] -0.120487738 -0.04944682 -0.42890984 -0.094340479 0.039563994
#> [16,] 0.222116137 0.20480798 -0.19317697 -0.030252144 -0.232402380
#> [17,] -0.341874135 0.07183697 -0.21779152 0.005895013 0.515569917
#> [18,] -0.366338640 -0.32114447 -0.13393835 0.227768968 0.375981910
#> [19,] 0.170401638 0.03940552 -0.37167687 -0.155215496 -0.303830963
#> [20,] -0.364663573 0.04660273 0.76923298 -0.089870264 0.004519800
#> [21,] -0.190678325 0.28827833 -0.23394600 -0.616141855 -0.091501802
#> [22,] 0.560558549 -0.11111111 -0.17778763 0.013676832 -0.218217890
#> [23,] -0.370555944 0.07881104 -0.37167687 -0.324982445 0.441414795
#> [24,] -0.470673067 -0.35714286 -0.18647650 -0.052753496 0.478001093
#> [25,] 0.380943482 -0.48337754 -0.34676957 0.242406031 0.078134538
#> [26,] -0.177638937 0.26958193 0.12259563 -0.351742366 0.141186242
#> [27,] 0.590907964 -0.35048636 -0.35419532 0.560844558 0.627792991
#> [28,] -0.498192010 -0.33916172 -0.12567531 -0.239354754 0.595378631
#> [29,] 0.696786528 -0.44876373 -0.10946858 0.706678204 -0.036019595
#> [30,] -0.546927644 0.17609018 0.57093454 -0.438922860 0.134491097
#> [31,] 0.044909656 0.57576631 0.02204012 -0.144965320 0.361698136
#> [32,] -0.277450596 0.08600261 0.88361266 -0.232896181 -0.187673091
#> [33,] 0.109877327 -0.35139096 -0.29263652 -0.175415908 -0.090879757
#> [34,] -0.055837755 0.10846523 0.54806521 0.367156536 -0.039448422
#> [35,] 0.439631108 0.06741999 -0.45422297 0.311205999 0.098081648
#> [36,] 0.319439173 -0.34615385 0.08421519 0.123091491 -0.117501941
#> [37,] 0.175913323 0.22613351 -0.29200611 0.408248290 -0.153522062
#> [38,] 0.491664182 -0.30096463 0.12165981 0.548283544 -0.166378864
#> [39,] 0.021744452 -0.07310553 0.22163746 0.128980912 -0.436046858
#> [40,] 0.069678305 -0.39043440 -0.53924034 0.285150975 0.420318876
#> [41,] 0.055197454 0.77979229 0.22163746 -0.395941405 0.343874351
#> [42,] 0.016079609 -0.27330408 0.34853339 0.004805915 -0.488478693
#> [43,] -0.117275549 -0.42714107 -0.03808775 -0.117526023 -0.007310574
#> [44,] -0.400503688 0.33448237 -0.06885633 -0.352248761 0.362246846
#> [45,] 0.367512406 -0.52613679 -0.31798016 0.487627009 0.616835573
#> [46,] 0.088736619 0.52732071 -0.22060954 -0.186350762 0.554319613
#> [47,] -0.224226368 -0.28718326 -0.16929636 -0.391057340 -0.334232138
#> [48,] 0.615613136 -0.20064309 -0.25007850 0.572981000 -0.078811041
#> [49,] 0.539976776 -0.43798113 -0.02553554 0.615838069 -0.139687003
#> [50,] -0.345882307 -0.36404079 -0.38402885 0.169807543 0.314973478
#> [51,] 0.735102343 -0.28270579 -0.03641242 0.837215248 -0.130640743
#> [52,] -0.037519087 -0.23426064 0.05260881 0.028835492 -0.545278541
#> [53,] 0.040001333 -0.58277152 -0.38035617 0.041844959 -0.332058058
#> [54,] -0.090545567 0.37280057 -0.32844493 -0.250622232 -0.433876018
#> [55,] -0.043272931 -0.17391304 -0.09886131 0.189989040 -0.256168828
#> [56,] 0.446158845 -0.27272727 -0.50529115 0.156661898 -0.416597790
#> [57,] 0.221366815 0.58358036 0.12933245 -0.434783386 -0.290442066
#> [58,] 0.071489150 -0.26037782 0.14253049 0.669049894 0.037879399
#> [59,] -0.211889383 0.45018379 0.15525995 -0.314011496 0.293155132
#> [60,] -0.138830876 -0.26967994 -0.02838894 0.124482399 0.098081648
#> [61,] -0.305641034 -0.43346072 -0.12610465 -0.232823244 0.017197979
#> [62,] 0.442919711 0.44502136 -0.17489528 -0.133902615 -0.363269401
#> [63,] 0.358583899 0.75862069 -0.26426146 -0.174025901 -0.132937335
#> [64,] 0.470963383 -0.31506302 -0.48349191 0.133580987 -0.081484311
#> [65,] 0.792997095 0.22360680 -0.25108119 0.596355373 0.162650012
#> [66,] 0.389635002 -0.07372098 -0.17383594 0.471870106 0.032174473
#> [67,] 0.082040279 0.17928429 0.02516410 0.349415870 -0.347760354
#> [68,] -0.293345857 -0.33106110 -0.35991028 0.159298597 0.359028074
#> [69,] -0.348977312 0.07862136 0.27808675 -0.254844013 -0.594761714
#> [70,] 0.073251552 -0.31234752 -0.24989186 -0.060874927 -0.230986049
#> [71,] 0.002565191 -0.35503167 -0.26437064 -0.087402755 0.293586676
#> [72,] -0.249777219 0.20879250 0.09545329 -0.089952028 0.008678525
#> [73,] -0.222333337 -0.10869565 0.17575344 -0.385329885 -0.161291484
#> [74,] -0.112755507 -0.05763904 0.48055421 0.223488581 -0.515692674
#> [75,] -0.297101415 0.12437965 0.01256959 -0.257209284 0.267799730
#> [76,] 0.273927682 0.59511904 -0.25353844 -0.262852909 -0.427792632
#> [77,] -0.377461846 -0.30751921 0.32905426 0.102425759 -0.200002770
#> [78,] -0.004902844 -0.11904762 -0.39701448 -0.169983488 -0.093521953
#> [79,] -0.336144456 -0.12311452 -0.30873937 -0.409167453 -0.143284220
#> [80,] -0.230947050 0.18089365 0.47834740 -0.113558993 -0.036842616
#> [81,] 0.378791242 0.53405175 -0.18489833 -0.142430656 -0.069060531
#> [82,] -0.079689878 0.24095937 0.86150632 -0.088980146 -0.245381017
#> [83,] 0.286077522 0.16390252 -0.35888013 -0.409264391 -0.197567121
#> [84,] 0.022467656 0.03636965 -0.11026357 -0.452156219 0.322751323
#> [85,] 0.209469803 0.13793103 -0.25845352 -0.091257485 -0.142970342
#> [86,] 0.366760261 0.15715464 -0.23066380 0.105012451 -0.222094177
#> [87,] -0.405170470 0.09310487 0.81231145 -0.245252917 -0.387380275
#> [88,] -0.358127720 -0.03726780 -0.34523664 -0.573418628 0.379516695
#> [89,] 0.011985033 -0.17460757 0.35291065 0.322390599 0.330221636
#> [90,] -0.197564473 -0.23211917 -0.12510695 0.160002612 0.351191056
#> [91,] -0.232446371 -0.09320546 -0.24594524 -0.263874392 0.696049197
#> [92,] -0.343529735 -0.14265511 -0.03604118 0.086334849 0.295734023
#> [93,] -0.378829716 -0.23287322 0.68247890 -0.249382989 -0.213431828
#> [94,] -0.211714850 -0.13665204 0.21701136 -0.187430697 -0.204479453
#> [,11] [,12] [,13] [,14] [,15]
#> [1,] -0.459578629 -0.07814525 -0.007993672 0.362719863 0.34762108
#> [2,] -0.280544650 0.03978311 -0.383382047 0.450103216 0.05926346
#> [3,] 0.055331862 -0.23588326 -0.409266393 -0.133350573 -0.40806202
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#> [,76] [,77] [,78] [,79] [,80]
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#> [13,] -0.197749344 -0.519806232 -0.396179778 -0.265415427 -0.279895663
#> [14,] 0.264732844 0.151196565 0.706002578 0.691464361 -0.151196565
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#> [16,] 0.252373911 -0.189688132 0.690495476 -0.040343739 -0.284532198
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